biostudies-literatureChagnon-Choquet JAlberta InnovatesCanadian Institutes of Health Researche101949https://www.ebi.ac.uk/biostudies/studies/S-EPMC4087016biostudies-literatureUnknown9(7)Understanding how the immune system facilitates or controls HIV-1 disease progression has important implications for the design of effective interventions. We report that although B-cell dysregulations associated with HIV-1 disease progression are accompanied by an overall decrease in the percentage of total blood B-cells, we observe an increase in relative frequencies of cells presenting characteristics of both transitional immature and first-line marginal zone (MZ) B-cell populations, we designated as precursor MZ-like B-cells. B-cells with similar attributes have been associated with IL-10 expression and "regulatory" potential. As such, the relative frequencies of precursor MZ-like B-cells expressing IL-10 are increased in the blood of viremic HIV-1-infected individuals when compared toPloS oneIL-10 and lymphotoxin-α expression profiles within marginal zone-like B-cell populations are associated with control of HIV-1 disease progression.PMC4087016126633201201140Vezina SHuchet EBernard NLessard BRouleau DRoger MCote PPoudrier JBaril JGCharron MABruneau JPotter MCharest Llalonde RThomas RVassal AMunoz MMilne CTremblay CSlow Progressor Study GroupLegault MGilmore NSzabo JKlein MMontreal Primary HIV Infection Study GroupFontaine Jde Pokomandy ALabrecque LFortin CTrottier BFriedman JRouty JPDufresne SLeBlanc RChagnon-Choquet JfalseIL-10 and lymphotoxin-α expression profiles within marginal zone-like B-cell populations are associated with control of HIV-1 disease progression.Understanding how the immune system facilitates or controls HIV-1 disease progression has important implications for the design of effective interventions. We report that although B-cell dysregulations associated with HIV-1 disease progression are accompanied by an overall decrease in the percentage of total blood B-cells, we observe an increase in relative frequencies of cells presenting characteristics of both transitional immature and first-line marginal zone (MZ) B-cell populations, we designated as precursor MZ-like B-cells. B-cells with similar attributes have been associated with IL-10 expression and "regulatory" potential. As such, the relative frequencies of precursor MZ-like B-cells expressing IL-10 are increased in the blood of viremic HIV-1-infected individuals when compared to2014-01-01T00:00:00Z20142025-04-18T21:44:00.576Z2019-03-26T23:26:26ZS-EPMC40870162500398910.1371/journal.pone.0101949