{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pires ES"],"funding":["NICHD NIH HHS","NCATS NIH HHS","FIC NIH HHS","NIH HHS"],"pagination":["1405-26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4091973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["242(12)"],"pubmed_abstract":["<h4>Background</h4>Sperm Acrosomal SLLP1 Binding (SAS1B) protein (ovastacin) is an oolemmal binding partner for the intra-acrosomal sperm protein SLLP1.<h4>Results</h4>Immunohistochemical localization revealed that SAS1B translation is restricted among adult tissues to the ovary and oocytes, SAS1B appearing first in follicles at the primary-secondary transition. Quiescent oocytes within primordial follicles and primary follicles did not stain for SAS1B. Examination of neonatal rat ovaries revealed SAS1B expression first as faint signals in postnatal day 3 oocytes, with SAS1B protein staining intensifying with oocyte growth. Irrespective of animal age or estrus stage, SAS1B was seen only in oocytes of follicles that initiated a second granulosa cell layer. The precise temporal and spatial o"],"journal":["Developmental dynamics : an official publication of the American Association of Anatomists"],"pubmed_title":["SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition."],"pmcid":["PMC4091973"],"funding_grant_id":["U01HD60491-2S1","P51OD010425","U01 HD060491","D43TW/HD00654","UL1 TR000423","R01 HD035523","U54 HD029099","D43 TW000654","P51 OD010425","R03 HD055129"],"pubmed_authors":["Flickinger C","Herr JC","Curnow E","Hlavin C","Mandal A","Klotz K","Shetty J","Ishola-Gbenla K","Macnamara E","Chertihin O","Khole A","Doerwaldt C","Herr AK","Chamberlain C","Feldman SH","Pires ES"],"additional_accession":[]},"is_claimable":false,"name":"SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition.","description":"<h4>Background</h4>Sperm Acrosomal SLLP1 Binding (SAS1B) protein (ovastacin) is an oolemmal binding partner for the intra-acrosomal sperm protein SLLP1.<h4>Results</h4>Immunohistochemical localization revealed that SAS1B translation is restricted among adult tissues to the ovary and oocytes, SAS1B appearing first in follicles at the primary-secondary transition. Quiescent oocytes within primordial follicles and primary follicles did not stain for SAS1B. Examination of neonatal rat ovaries revealed SAS1B expression first as faint signals in postnatal day 3 oocytes, with SAS1B protein staining intensifying with oocyte growth. Irrespective of animal age or estrus stage, SAS1B was seen only in oocytes of follicles that initiated a second granulosa cell layer. The precise temporal and spatial o","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Dec","modification":"2025-04-04T19:24:12.968Z","creation":"2019-06-06T13:00:47Z"},"accession":"S-EPMC4091973","cross_references":{"pubmed":["24038607"],"doi":["10.1002/dvdy.24040"]}}