{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Lill CM"],"pubmed_abstract":["Multiple sclerosis (MS) is the most common auto-inflammatory disease of the central nervous system, affecting more than 2 million individuals worldwide. It is a genetically complex disease, in which a substantial part of a person's liability to develop MS is caused by a combination of multiple genetic and non-genetic (e.g., environmental) risk factors. Increasing this complexity, many of the involved risk factors likely interact in an intricate and hitherto ill-defined fashion. Despite these complexities, and owing greatly to the advent and application of large-scale genome-wide association studies, our understanding of the genetic factors underlying MS etiology has begun to gain unprecedented momentum. In this perspective, I will summarize some recent advances and outline future challenges in MS genetics research."],"journal":["Frontiers in neurology"],"pagination":["130"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4094909"],"repository":["biostudies-literature"],"pubmed_title":["Recent advances and future challenges in the genetics of multiple sclerosis."],"pmcid":["PMC4094909"],"pubmed_authors":["Lill CM"],"additional_accession":[]},"is_claimable":false,"name":"Recent advances and future challenges in the genetics of multiple sclerosis.","description":"Multiple sclerosis (MS) is the most common auto-inflammatory disease of the central nervous system, affecting more than 2 million individuals worldwide. It is a genetically complex disease, in which a substantial part of a person's liability to develop MS is caused by a combination of multiple genetic and non-genetic (e.g., environmental) risk factors. Increasing this complexity, many of the involved risk factors likely interact in an intricate and hitherto ill-defined fashion. Despite these complexities, and owing greatly to the advent and application of large-scale genome-wide association studies, our understanding of the genetic factors underlying MS etiology has begun to gain unprecedented momentum. In this perspective, I will summarize some recent advances and outline future challenges in MS genetics research.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-19T19:10:02.483Z","creation":"2019-03-27T01:31:56Z"},"accession":"S-EPMC4094909","cross_references":{"pubmed":["25071715"],"doi":["10.3389/fneur.2014.00130"]}}