biostudies-literatureUnknown37(7)Lo JC<h4>Study objectives</h4>To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults.<h4>Design</h4>Community-based longitudinal brain and cognitive aging study using a convenience sample.<h4>Setting</h4>Participants were studied in a research laboratory.<h4>Participants</h4>Relatively healthy adults aged 55 y and older at study commencement.<h4>Interventions</h4>N/A.<h4>Measurements and results</h4>Participants underwent magnetic resonance imaging and neuropsychological assessment every 2 y. Subjective assessments of sleep duration and quality and blood samples were obtained. Each hour of reduced sleep duration at baseline augmented the annual expansion rate of the ventricles by 0.59% (P = 0.007) and the annual decline rate in global cognitive performance by 0.67% (P = 0.050) in the subsequent 2 y after controlling for the effects of age, sex, education, and body mass index. In contrast, global sleep quality at baseline did not modulate either brain or cognitive aging. High-sensitivity C-reactive protein, a marker of systemic inflammation, showed no correlation with baseline sleep duration, brain structure, or cognitive performance.<h4>Conclusions</h4>In healthy older adults, short sleep duration is associated with greater age-related brain atrophy and cognitive decline. These associations are not associated with elevated inflammatory responses among short sleepers.<h4>Citation</h4>Lo JC, Loh KK, Zheng H, Sim SK, Chee MW. Sleep duration and age-related changes in brain structure and cognitive performance.Sleep1171-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4098802biostudies-literatureSleep duration and age-related changes in brain structure and cognitive performance.PMC4098802Chee MWZheng HLo JCLoh KKSim SKfalseSleep duration and age-related changes in brain structure and cognitive performance.<h4>Study objectives</h4>To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults.<h4>Design</h4>Community-based longitudinal brain and cognitive aging study using a convenience sample.<h4>Setting</h4>Participants were studied in a research laboratory.<h4>Participants</h4>Relatively healthy adults aged 55 y and older at study commencement.<h4>Interventions</h4>N/A.<h4>Measurements and results</h4>Participants underwent magnetic resonance imaging and neuropsychological assessment every 2 y. Subjective assessments of sleep duration and quality and blood samples were obtained. Each hour of reduced sleep duration at baseline augmented the annual expansion rate of the ventricles by 0.59% (P = 0.007) and the annual decline rate in global cognitive performance by 0.67% (P = 0.050) in the subsequent 2 y after controlling for the effects of age, sex, education, and body mass index. In contrast, global sleep quality at baseline did not modulate either brain or cognitive aging. High-sensitivity C-reactive protein, a marker of systemic inflammation, showed no correlation with baseline sleep duration, brain structure, or cognitive performance.<h4>Conclusions</h4>In healthy older adults, short sleep duration is associated with greater age-related brain atrophy and cognitive decline. These associations are not associated with elevated inflammatory responses among short sleepers.<h4>Citation</h4>Lo JC, Loh KK, Zheng H, Sim SK, Chee MW. Sleep duration and age-related changes in brain structure and cognitive performance.2014-01-01T00:00:00Z2014 Jul2025-04-19T11:20:53.098Z2019-03-27T01:32:05ZS-EPMC40988022506124510.5665/sleep.3832