{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rossi F"],"funding":["NIAID NIH HHS","NHGRI NIH HHS"],"pagination":["1524-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4112484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["370(16)"],"pubmed_abstract":["We report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cluster during antibiotic therapy and became resistant to vancomycin (designated BR-VRSA). Both strains belong to the sequence type (ST) 8 community-associated genetic lineage that carries the staphylococcal chromosomal cassette mec (SCCmec) type IVa and the S. aureus protein A gene (spa) type t292 and are phylogenetically related to MRSA lineage USA300. A conjugative plasmid of 55,706 bp (pBRZ01) carrying the vanA cluster was identified and readily transferred to other staphylococci. The pBRZ01 plasmid harbors DNA sequences that are typical of the plasmid-associated replication genes rep24 or rep21 described in community-associated MRSA strains from Australia (pWBG745). The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern."],"journal":["The New England journal of medicine"],"pubmed_title":["Transferable vancomycin resistance in a community-associated MRSA lineage."],"pmcid":["PMC4112484"],"funding_grant_id":["U54 HG004968","1U54 HG004968","R01 AI093749","U54 HG003079","K08 AI101005"],"pubmed_authors":["Rossi F","Wollam A","Tran TT","Weinstock GM","Zhou Y","Panesso D","Doi A","Hernandez-Roldan A","Narechania A","Reyes J","Brandao D","Rincon S","Xing G","Diaz L","Planet PJ","Carvajal LP","Di Gioia TS","Munita JM","van der Heijden IM","Murray BE","Arias CA"],"additional_accession":[]},"is_claimable":false,"name":"Transferable vancomycin resistance in a community-associated MRSA lineage.","description":"We report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cluster during antibiotic therapy and became resistant to vancomycin (designated BR-VRSA). Both strains belong to the sequence type (ST) 8 community-associated genetic lineage that carries the staphylococcal chromosomal cassette mec (SCCmec) type IVa and the S. aureus protein A gene (spa) type t292 and are phylogenetically related to MRSA lineage USA300. A conjugative plasmid of 55,706 bp (pBRZ01) carrying the vanA cluster was identified and readily transferred to other staphylococci. The pBRZ01 plasmid harbors DNA sequences that are typical of the plasmid-associated replication genes rep24 or rep21 described in community-associated MRSA strains from Australia (pWBG745). The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Apr","modification":"2024-11-11T18:39:01.493Z","creation":"2019-03-27T01:32:54Z"},"accession":"S-EPMC4112484","cross_references":{"pubmed":["24738669"],"doi":["10.1056/nejmoa1303359","10.1056/NEJMoa1303359"]}}