biostudies-literatureColinge JAustrian Science Fund FWF113-27https://www.ebi.ac.uk/biostudies/studies/S-EPMC4115268biostudies-literatureUnknown107Biological matter is organized in functional networks of different natures among which kinase-substrate and protein-protein interactions play an important role. Large public data collections allowed us to compile an important corpus of interaction data around human protein kinases. One of the most interesting observations analyzing this network is that coherence in kinase functional activity relies on kinase substrate interactions primarily and not on which protein complexes are formed around them. Further dissecting the two types of interactions at the level of kinase groups (CMGCs, Tyrosine kinases, etc.) we show a prevalence of intra-group interconnectivity, which we can naturally relate to current scenarios of evolution of biological networks. Tracking publication dates we observe highJournal of proteomicsBuilding and exploring an integrated human kinase network: global organization and medical entry points.PMC4115268P 24321P 24321-B21Huber KMajek PSuperti-Furga GColinge JCesar-Razquin ABreitwieser FPfalseBuilding and exploring an integrated human kinase network: global organization and medical entry points.Biological matter is organized in functional networks of different natures among which kinase-substrate and protein-protein interactions play an important role. Large public data collections allowed us to compile an important corpus of interaction data around human protein kinases. One of the most interesting observations analyzing this network is that coherence in kinase functional activity relies on kinase substrate interactions primarily and not on which protein complexes are formed around them. Further dissecting the two types of interactions at the level of kinase groups (CMGCs, Tyrosine kinases, etc.) we show a prevalence of intra-group interconnectivity, which we can naturally relate to current scenarios of evolution of biological networks. Tracking publication dates we observe high2014-01-01T00:00:00Z2014 Jul2025-04-19T06:24:30.923Z2019-03-27T01:33:02ZS-EPMC41152682470485910.1016/j.jprot.2014.03.028