{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoggart CJ"],"funding":["Economic and Social Research Council","British Heart Foundation","NCRR NIH HHS","NIDA NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","NIAAA NIH HHS","RNID","Swiss National Science Foundation","NIDDK NIH HHS","Medical Research Council","Dutch Research Council (NWO)","Chief Scientist Office","NHGRI NIH HHS","National Institute for Health Research (NIHR)","Wellcome Trust","Novo Nordisk Fonden","PHS HHS","Biotechnology and Biological Sciences Research Council"],"pagination":["e1004508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4117451"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(7)"],"pubmed_abstract":["The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective mater"],"journal":["PLoS genetics"],"pubmed_title":["Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index."],"pmcid":["PMC4117451"],"funding_grant_id":["AA13320","G0500539","10371","NNF13OC0005785","R01 DA012854","0927310","R01 HL087679","R01 HL059367","HHSN268201100009I","HHSN268201100005C","T32 HL091823","NF-SI-0513-10151","P30 DK079637","NNF14OC0010513","UL1 RR025005","HHSN268201100009C","RG/09/012/28096","AA13321","G0100266","HHSN268201100005I","MC_PC_15018","T32 HL007055","R01HL087641","AA13326","HHSN268201100005G","R01 AA007535","R01 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We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective mater","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-05-04T23:22:14.549Z","creation":"2019-03-27T01:33:08Z"},"accession":"S-EPMC4117451","cross_references":{"pubmed":["25078964"],"doi":["10.1371/journal.pgen.1004508"]}}