{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(7)"],"submitter":["Kunicka T"],"pubmed_abstract":["<h4>Objectives</h4>ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients.<h4>Methods</h4>The distribution of twelve ABCC1 polymorphisms was assessed by direct sequencing in peripheral blood DNA (n = 540).<h4>Results</h4>Tumors from carriers of the wild type genotype in rs35623 or rs35628 exhibited significantly lower levels of ABCC1 transcript than those from carrie"],"journal":["PloS one"],"pagination":["e101740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4117604"],"repository":["biostudies-literature"],"pubmed_title":["Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer."],"pmcid":["PMC4117604"],"pubmed_authors":["Vaclavikova R","Pecha V","Raus K","Vodickova L","Vrana D","Hlavac V","Vodicka P","Kubackova K","Ambrus M","Kunicka T","Trnkova M","Soucek P"],"additional_accession":[]},"is_claimable":false,"name":"Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.","description":"<h4>Objectives</h4>ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients.<h4>Methods</h4>The distribution of twelve ABCC1 polymorphisms was assessed by direct sequencing in peripheral blood DNA (n = 540).<h4>Results</h4>Tumors from carriers of the wild type genotype in rs35623 or rs35628 exhibited significantly lower levels of ABCC1 transcript than those from carrie","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2026-05-01T19:43:01.129Z","creation":"2019-03-26T23:26:40Z"},"accession":"S-EPMC4117604","cross_references":{"pubmed":["25078270"],"doi":["10.1371/journal.pone.0101740"]}}