biostudies-literatureUnknown9(7)Kunicka T<h4>Objectives</h4>ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients.<h4>Methods</h4>The distribution of twelve ABCC1 polymorphisms was assessed by direct sequencing in peripheral blood DNA (n = 540).<h4>Results</h4>Tumors from carriers of the wild type genotype in rs35623 or rs35628 exhibited significantly lower levels of ABCC1 transcript than those from carriePloS onee101740https://www.ebi.ac.uk/biostudies/studies/S-EPMC4117604biostudies-literatureNon-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.PMC4117604Vaclavikova RPecha VRaus KVodickova LVrana DHlavac VVodicka PKubackova KAmbrus MKunicka TTrnkova MSoucek PfalseNon-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.<h4>Objectives</h4>ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients.<h4>Methods</h4>The distribution of twelve ABCC1 polymorphisms was assessed by direct sequencing in peripheral blood DNA (n = 540).<h4>Results</h4>Tumors from carriers of the wild type genotype in rs35623 or rs35628 exhibited significantly lower levels of ABCC1 transcript than those from carrie2014-01-01T00:00:00Z20142026-05-01T19:43:01.129Z2019-03-26T23:26:40ZS-EPMC41176042507827010.1371/journal.pone.0101740