{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(7)"],"submitter":["Kandasamy M"],"pubmed_abstract":["Members of the transforming growth factor (TGF)-β family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance. This clearly created some discrepancies in the field with some studies favouring neuronal differentiation/survival of progenitors and others favouring cell cycle exit and neural stem cell quiescence/maintenance. Here, we provide a unifying hypothesis claiming that through its regulation of neural progenitor cell (NPC) proliferation, TGF-β signalling might be responsible for (i) maintaining stem cells in a quiescent stage, and (ii) promoting survival of newly generated neurons and their functional differentiation. Therefore, we performed a d"],"journal":["Journal of cellular and molecular medicine"],"pagination":["1444-59"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4124027"],"repository":["biostudies-literature"],"pubmed_title":["TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons."],"pmcid":["PMC4124027"],"pubmed_authors":["Reitsamer HA","Kraus S","Sander PR","Bogdahn U","Kandasamy M","Lehner B","Couillard-Despres S","Ueberham U","Aigner L","Marschallinger J","Rivera FJ","Trumbach D","Strauss O"],"additional_accession":[]},"is_claimable":false,"name":"TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons.","description":"Members of the transforming growth factor (TGF)-β family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance. This clearly created some discrepancies in the field with some studies favouring neuronal differentiation/survival of progenitors and others favouring cell cycle exit and neural stem cell quiescence/maintenance. Here, we provide a unifying hypothesis claiming that through its regulation of neural progenitor cell (NPC) proliferation, TGF-β signalling might be responsible for (i) maintaining stem cells in a quiescent stage, and (ii) promoting survival of newly generated neurons and their functional differentiation. Therefore, we performed a d","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-04-30T13:32:46.028Z","creation":"2026-04-07T16:04:25.662Z"},"accession":"S-EPMC4124027","cross_references":{"pubmed":["24779367"],"doi":["10.1111/jcmm.12298"]}}