biostudies-literatureSchug TTNIEHS NIH HHS181-198https://www.ebi.ac.uk/biostudies/studies/S-EPMC4125359biostudies-literatureUnknown15(1)A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. Endocrine disruption is a type of hazard that to date has been inadequately addressed by both industrial and regulatory science. To aid chemists in avoiding this hazard, we propose an endocrine disruption testing protocol for use by chemists in the design of new chemicals. The Tiered Protocol for Endocrine Disruption (TiPED) has been created under the oversight of a scientific advisory committee composed of leading representatives from both green chemistry and the environmental health sciences. TiPED is conceived as a tool for new chemical design, thus it sGreen chemistry : an international journal and green chemistry resource : GCDesigning Endocrine Disruption Out of the Next Generation of Chemicals.PMC4125359R13 ES016981Collins TJZoeller RTBlumberg BHeindel JJO'Brien KPGuillette LJDickerson SMTal TLCrews DDeFur PLSaal FSEdwards TMMyers JPPatisaul HBSchug TTThayer KAWarner JAbagyan RMoores AWatson CSVandenberg LNHayes TGore ACfalseDesigning Endocrine Disruption Out of the Next Generation of Chemicals.A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. Endocrine disruption is a type of hazard that to date has been inadequately addressed by both industrial and regulatory science. To aid chemists in avoiding this hazard, we propose an endocrine disruption testing protocol for use by chemists in the design of new chemicals. The Tiered Protocol for Endocrine Disruption (TiPED) has been created under the oversight of a scientific advisory committee composed of leading representatives from both green chemistry and the environmental health sciences. TiPED is conceived as a tool for new chemical design, thus it s2013-01-01T00:00:00Z2013 Jan2025-04-22T04:38:00.356Z2019-03-27T01:33:37ZS-EPMC41253592511046110.1039/C2GC35055F10.1039/c2gc35055f