{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leenders M"],"funding":["Intramural NIH HHS","Cancer Research UK","Medical Research Council","National Institute for Health Research (NIHR)","NCI NIH HHS"],"pagination":["595-602"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4127987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["Purpose
The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed.Methods
Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (<0.02) were followed up in 2,323 cases and 2,340 controls from eight case-control studies (PanC4) that participated in PanScan2. The correlation of SNPs with metabolite levels was assessed for 649 controls from the European Prospective Inves"],"journal":["Cancer causes & control : CCC"],"pubmed_title":["Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4."],"pmcid":["PMC4127987"],"funding_grant_id":["G0801056B","G1000143","P50 CA102701","P30 CA008748","ZIA CP010193","G0401527","NF-SI-0512-10114","14136","R37 CA070867"],"pubmed_authors":["Wactawski-Wende J","Hartge P","Hankinson SE","Trichopoulos D","Bueno-de-Mesquita HB","Giovanucci EL","Tjonneland A","Visvanathan K","Holly EA","Jacobs EJ","Cotterchio M","Hallmans G","Zeleniuch-Jacquotte A","Bracci PM","LaCroix A","Chanock SJ","Mandelson MT","Jenab M","Virtamo J","Li D","Buring JE","Zheng W","Vineis P","Arslan AA","Rabe KG","Wolpin BM","Mendelsohn JB","Kurtz RC","Kraft P","Canzian F","McWilliams RR","Stevens V","Hutchinson A","Jacobs KB","Olson SH","Hoffman-Bolton JA","Tobias GS","Petersen G","Leenders M","Yu K","Hunter DJ","Goggins M","Khaw KT","Yu H","Boutron-Ruault MC","Agalliu I","Gallinger S","Hoover RN","Krogh V","Bhattacharjee S","Riboli E","Chang K","Gross M","Shu XO","Patel AV","Klein AP","Albanes D","Duell EJ","Risch HA","Kooperberg C","Fuchs CS","Stolzenberg-Solomon RZ","Elena JW","Gaziano JM","Amundadottir L"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4.","description":"Purpose
The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed.Methods
Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (<0.02) were followed up in 2,323 cases and 2,340 controls from eight case-control studies (PanC4) that participated in PanScan2. The correlation of SNPs with metabolite levels was assessed for 649 controls from the European Prospective Inves","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2026-05-04T22:12:35.335Z","creation":"2019-03-27T01:33:47Z"},"accession":"S-EPMC4127987","cross_references":{"pubmed":["23334854"],"doi":["10.1007/s10552-012-0138-0"]}}