{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(9)"],"submitter":["Lu W"],"pubmed_abstract":["Cancer stem cells (CSCs) may contribute to tumor initiation, distant metastasis and chemo-resistance. One of RNA-binding proteins, Quaking (QKI), was reported to be a tumor suppressor. Here we showed that reduced QKI levels were observed in many human oral cancer samples. Moreover further reduction of QKI expression in CSCs was detected compared with non-CSCs in oral cancer cell lines. Overexpressing QKI in oral cancer cells significantly reduced CSC sphere formation and stem cell-associated genes. In tumor implanting nude mice model, QKI significantly impeded tumor initiation rates, tumor sizes and lung metastasis rates. As a contrast, knocking down QKI enhanced the above effects. Among the putative CSC target genes, SOX2 expression was negatively affected by QKI, mechanism study revealed"],"journal":["Cancer biology & therapy"],"pagination":["1174-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4128860"],"repository":["biostudies-literature"],"pubmed_title":["QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2."],"pmcid":["PMC4128860"],"pubmed_authors":["Wei M","Yang G","Liu Y","Lu W","Lu X","Lu H","Wang S","Lei X","Lu Z","Feng F","Xu J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2.","description":"Cancer stem cells (CSCs) may contribute to tumor initiation, distant metastasis and chemo-resistance. One of RNA-binding proteins, Quaking (QKI), was reported to be a tumor suppressor. Here we showed that reduced QKI levels were observed in many human oral cancer samples. Moreover further reduction of QKI expression in CSCs was detected compared with non-CSCs in oral cancer cell lines. Overexpressing QKI in oral cancer cells significantly reduced CSC sphere formation and stem cell-associated genes. In tumor implanting nude mice model, QKI significantly impeded tumor initiation rates, tumor sizes and lung metastasis rates. As a contrast, knocking down QKI enhanced the above effects. Among the putative CSC target genes, SOX2 expression was negatively affected by QKI, mechanism study revealed","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-22T18:00:37.627Z","creation":"2019-03-27T01:33:50Z"},"accession":"S-EPMC4128860","cross_references":{"pubmed":["24918581"],"doi":["10.4161/cbt.29502"]}}