{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(9)"],"submitter":["Lebron MB"],"pubmed_abstract":["Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of more specific and effective c-Kit therapies is warranted given its essential role in tumorigenesis. In this study, we describe the biological properties of CK6, a fully human IgG1 monoclonal antibody against the extracellular region of human c-Kit. CK6 specifically binds c-Kit receptor with high affinity (EC 50 = 0.06 nM) and strongly blocks its interaction with SCF (IC 50 = 0.41 nM) in solid phase assays. Flow cytometry shows CK6 binding to c-Kit on the cell surface of human small cell lung carcinoma (SCLC), melanoma, a"],"journal":["Cancer biology & therapy"],"pagination":["1208-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4128863"],"repository":["biostudies-literature"],"pubmed_title":["A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth."],"pmcid":["PMC4128863"],"pubmed_authors":["Paz K","Loizos N","Starodubtseva M","Credille KM","Schwartz KD","Surguladze D","Damoci CB","Lebron MB","Persaud K","Duignan IJ","Zhang Y","Balderes P","Amatulli M","Kotanides H","Burtrum D","DeLigio JT","Brennan L","O'Mahony M","Prewett MC"],"additional_accession":[]},"is_claimable":false,"name":"A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.","description":"Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of more specific and effective c-Kit therapies is warranted given its essential role in tumorigenesis. In this study, we describe the biological properties of CK6, a fully human IgG1 monoclonal antibody against the extracellular region of human c-Kit. CK6 specifically binds c-Kit receptor with high affinity (EC 50 = 0.06 nM) and strongly blocks its interaction with SCF (IC 50 = 0.41 nM) in solid phase assays. Flow cytometry shows CK6 binding to c-Kit on the cell surface of human small cell lung carcinoma (SCLC), melanoma, a","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-22T18:00:59.434Z","creation":"2019-03-27T01:33:49Z"},"accession":"S-EPMC4128863","cross_references":{"pubmed":["24921944"],"doi":["10.4161/cbt.29523"]}}