{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weible AP"],"funding":["NICHD NIH HHS","NIDCD NIH HHS","NIMH NIH HHS"],"pagination":["1447-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4131718"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(13)"],"pubmed_abstract":["<h4>Background</h4>Understanding speech in the presence of background noise often becomes increasingly difficult with age. These age-related speech processing deficits reflect impairments in temporal acuity. Gap detection is a model for temporal acuity in speech processing in which a gap inserted in white noise acts as a cue that attenuates subsequent startle responses. Lesion studies have shown that auditory cortex is necessary for the detection of brief gaps, and auditory cortical neurons respond to the end of the gap with a characteristic burst of spikes called the gap termination response (GTR). However, it remains unknown whether and how the GTR plays a causal role in gap detection. We tested this by optogenetically suppressing the activity of somatostatin- or parvalbumin-expressing i"],"journal":["Current biology : CB"],"pubmed_title":["Perceptual gap detection is mediated by gap termination responses in auditory cortex."],"pmcid":["PMC4131718"],"funding_grant_id":["1R01DC011379","R01 DC011379","R25 HD070817","R01 MH097130"],"pubmed_authors":["Wehr M","Kentros C","Moore AK","Liu C","DeBlander L","Weible AP","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Perceptual gap detection is mediated by gap termination responses in auditory cortex.","description":"<h4>Background</h4>Understanding speech in the presence of background noise often becomes increasingly difficult with age. These age-related speech processing deficits reflect impairments in temporal acuity. Gap detection is a model for temporal acuity in speech processing in which a gap inserted in white noise acts as a cue that attenuates subsequent startle responses. Lesion studies have shown that auditory cortex is necessary for the detection of brief gaps, and auditory cortical neurons respond to the end of the gap with a characteristic burst of spikes called the gap termination response (GTR). However, it remains unknown whether and how the GTR plays a causal role in gap detection. We tested this by optogenetically suppressing the activity of somatostatin- or parvalbumin-expressing i","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-04-13T19:33:43.186Z","creation":"2019-03-27T01:34:00Z"},"accession":"S-EPMC4131718","cross_references":{"pubmed":["24980499"],"doi":["10.1016/j.cub.2014.05.031"]}}