{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["58(9)"],"submitter":["Frangipani E"],"pubmed_abstract":["Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon."],"journal":["Antimicrobial agents and chemotherapy"],"pagination":["5572-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4135843"],"repository":["biostudies-literature"],"pubmed_title":["Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa."],"pmcid":["PMC4135843"],"pubmed_authors":["Minandri F","Imperi F","Visca P","Frangipani E","Bonchi C"],"additional_accession":[]},"is_claimable":false,"name":"Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.","description":"Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-22T00:57:27.34Z","creation":"2019-03-27T01:34:14Z"},"accession":"S-EPMC4135843","cross_references":{"pubmed":["24957826"],"doi":["10.1128/aac.03154-14","10.1128/AAC.03154-14"]}}