biostudies-literatureUnknown58(9)Frangipani EGallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.Antimicrobial agents and chemotherapy5572-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC4135843biostudies-literaturePyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.PMC4135843Minandri FImperi FVisca PFrangipani EBonchi CfalsePyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.2014-01-01T00:00:00Z2014 Sep2025-04-22T00:57:27.34Z2019-03-27T01:34:14ZS-EPMC41358432495782610.1128/aac.03154-1410.1128/AAC.03154-14