{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["111(32)"],"submitter":["Ise W"],"pubmed_abstract":["In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (TFH) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5(+) TFH memory cells, and thus subsequent recall antibody response, require Bcl6 expression. Furthermore, we show that, upon rechallenge with soluble antigen Bcl6 in memory TFH cells is rapidly induced in a dendritic cell-independent manner and that peptide:class II complexes (pMHC) on cognate memory B cells significantly contribute to this induction. Given the previous evidence that antigen-specific B cells residing in the follicles acquire antigens within minutes of injection, our results suggest that memory B cells present antigens to the co"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["11792-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4136626"],"repository":["biostudies-literature"],"pubmed_title":["Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells."],"pmcid":["PMC4136626"],"pubmed_authors":["Inoue T","McLachlan JB","Ise W","Kometani K","Kurosaki T","Kubo M","Okada T"],"additional_accession":[]},"is_claimable":false,"name":"Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells.","description":"In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (TFH) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5(+) TFH memory cells, and thus subsequent recall antibody response, require Bcl6 expression. Furthermore, we show that, upon rechallenge with soluble antigen Bcl6 in memory TFH cells is rapidly induced in a dendritic cell-independent manner and that peptide:class II complexes (pMHC) on cognate memory B cells significantly contribute to this induction. Given the previous evidence that antigen-specific B cells residing in the follicles acquire antigens within minutes of injection, our results suggest that memory B cells present antigens to the co","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2025-04-19T11:21:56.806Z","creation":"2019-03-27T01:34:17Z"},"accession":"S-EPMC4136626","cross_references":{"pubmed":["25071203"],"doi":["10.1073/pnas.1404671111"]}}