biostudies-literatureUnknown9(8)Huang SYA suitable small animal model may help in the screening and evaluation of new drugs, especially those from natural products, which can be administered at lower dosages, fulfilling an urgent worldwide need. In this study, we explore whether zebrafish could be a model organism for carrageenan-induced abdominal edema. The research results showed that intraperitoneal (i.p.) administration of 1.5% λ-carrageenan in a volume of 20 µL significantly increased abdominal edema in adult zebrafish. Levels of the proinflammatory proteins tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) were increased in carrageenan-injected adult zebrafish during the development of abdominal edema. An associated enhancement was also observed in the leukocyte marker, myeloperoxidase (MPO). To suPloS onee104414https://www.ebi.ac.uk/biostudies/studies/S-EPMC4139260biostudies-literatureA novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema.PMC4139260Hsiao CDWang HMWu CYHuang SYChakraborty CChen CHSun YMLiu WHung HCFeng CWJean YHWen ZHChen WFSung CSfalseA novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema.A suitable small animal model may help in the screening and evaluation of new drugs, especially those from natural products, which can be administered at lower dosages, fulfilling an urgent worldwide need. In this study, we explore whether zebrafish could be a model organism for carrageenan-induced abdominal edema. The research results showed that intraperitoneal (i.p.) administration of 1.5% λ-carrageenan in a volume of 20 µL significantly increased abdominal edema in adult zebrafish. Levels of the proinflammatory proteins tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) were increased in carrageenan-injected adult zebrafish during the development of abdominal edema. An associated enhancement was also observed in the leukocyte marker, myeloperoxidase (MPO). To su2014-01-01T00:00:00Z20142026-04-08T16:11:57.289Z2019-03-26T23:26:54ZS-EPMC41392602514100410.1371/journal.pone.0104414