{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baber U"],"funding":["NHLBI NIH HHS","NINDS NIH HHS"],"pagination":["373-380.e2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4139360"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["166(2)"],"pubmed_abstract":["<h4>Background</h4>Lipid-lowering guidelines endorse a low-density lipoprotein cholesterol goal of <100 mg/dL for people with coronary heart disease (CHD). A more stringent threshold of <70 mg/dL is recommended for those with CHD and \"very high-risk\" conditions such as diabetes mellitus, metabolic syndrome, or cigarette smoking. Whether chronic kidney disease (CKD) confers a similar risk for recurrent CHD events is unknown.<h4>Methods and results</h4>We evaluated the risk for recurrent CHD events and all-cause mortality among 3,938 participants ≥45 years with CHD in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Chronic kidney disease was defined by estimated glomerular filtration rate <60 mL/min per 1.73 m(2) or urinary albumin to creatinine ratio ≥30 mg/g. P"],"journal":["American heart journal"],"pubmed_title":["Risk for recurrent coronary heart disease and all-cause mortality among individuals with chronic kidney disease compared with diabetes mellitus, metabolic syndrome, and cigarette smokers."],"pmcid":["PMC4139360"],"funding_grant_id":["U01 NS041588","U01NS041588","R01 HL080477"],"pubmed_authors":["Baber U","Muntner P","Safford MM","Farkouh ME","Tonelli M","Gutierrez OM","Warnock DG","Levitan EB"],"additional_accession":[]},"is_claimable":false,"name":"Risk for recurrent coronary heart disease and all-cause mortality among individuals with chronic kidney disease compared with diabetes mellitus, metabolic syndrome, and cigarette smokers.","description":"<h4>Background</h4>Lipid-lowering guidelines endorse a low-density lipoprotein cholesterol goal of <100 mg/dL for people with coronary heart disease (CHD). A more stringent threshold of <70 mg/dL is recommended for those with CHD and \"very high-risk\" conditions such as diabetes mellitus, metabolic syndrome, or cigarette smoking. Whether chronic kidney disease (CKD) confers a similar risk for recurrent CHD events is unknown.<h4>Methods and results</h4>We evaluated the risk for recurrent CHD events and all-cause mortality among 3,938 participants ≥45 years with CHD in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Chronic kidney disease was defined by estimated glomerular filtration rate <60 mL/min per 1.73 m(2) or urinary albumin to creatinine ratio ≥30 mg/g. P","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Aug","modification":"2025-04-18T21:46:16.43Z","creation":"2019-03-27T01:34:25Z"},"accession":"S-EPMC4139360","cross_references":{"pubmed":["23895822"],"doi":["10.1016/j.ahj.2013.05.008"]}}