{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Knox DB"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["780-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4140959"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(5)"],"pubmed_abstract":["<h4>Objective</h4>The Sequential Organ Failure Assessment (SOFA) score, a measure of multiple-organ dysfunction syndrome, is used to predict mortality in critically ill patients by assigning equally weighted scores across 6 different organ systems. We hypothesized that specific organ systems would have a greater association with mortality than others.<h4>Design</h4>We retrospectively studied patients admitted over a period of 4.2 years to a mixed-profile intensive care unit (ICU). We recorded age and comorbidities, and calculated SOFA organ scores. The primary outcome was 30-day all-cause mortality. We determined which organ subscores of the SOFA score were most associated with mortality using multiple analytic methods: random forests, conditional inference trees, distanced-based clustering techniques, and logistic regression.<h4>Setting</h4>A 24-bed mixed-profile adult ICU that cares for medical, surgical, and trauma (level 1) patients at an academic referral center.<h4>Patients</h4>All patients' first admission to the study ICU during the study period.<h4>Measurements and main results</h4>We identified 9120 first admissions during the study period. Overall 30-day mortality was 12%. Multiple analytical methods all demonstrated that the best initial prediction variables were age and the central nervous system SOFA subscore, which is determined solely by Glasgow Coma Scale score.<h4>Conclusions</h4>In a mixed population of critically ill patients, the Glasgow Coma Scale score dominates the association between admission SOFA score and 30-day mortality. Future research into outcomes from multiple-organ dysfunction may benefit from new models for measuring organ dysfunction with special attention to neurologic dysfunction."],"journal":["Journal of critical care"],"pubmed_title":["Glasgow Coma Scale score dominates the association between admission Sequential Organ Failure Assessment score and 30-day mortality in a mixed intensive care unit population."],"pmcid":["PMC4140959"],"funding_grant_id":["K23GM094465","K23 GM094465"],"pubmed_authors":["Lanspa MJ","Kuttler KG","Knox DB","Pratt CM","Brown SM","Jones JP"],"additional_accession":[]},"is_claimable":false,"name":"Glasgow Coma Scale score dominates the association between admission Sequential Organ Failure Assessment score and 30-day mortality in a mixed intensive care unit population.","description":"<h4>Objective</h4>The Sequential Organ Failure Assessment (SOFA) score, a measure of multiple-organ dysfunction syndrome, is used to predict mortality in critically ill patients by assigning equally weighted scores across 6 different organ systems. We hypothesized that specific organ systems would have a greater association with mortality than others.<h4>Design</h4>We retrospectively studied patients admitted over a period of 4.2 years to a mixed-profile intensive care unit (ICU). We recorded age and comorbidities, and calculated SOFA organ scores. The primary outcome was 30-day all-cause mortality. We determined which organ subscores of the SOFA score were most associated with mortality using multiple analytic methods: random forests, conditional inference trees, distanced-based clustering techniques, and logistic regression.<h4>Setting</h4>A 24-bed mixed-profile adult ICU that cares for medical, surgical, and trauma (level 1) patients at an academic referral center.<h4>Patients</h4>All patients' first admission to the study ICU during the study period.<h4>Measurements and main results</h4>We identified 9120 first admissions during the study period. Overall 30-day mortality was 12%. Multiple analytical methods all demonstrated that the best initial prediction variables were age and the central nervous system SOFA subscore, which is determined solely by Glasgow Coma Scale score.<h4>Conclusions</h4>In a mixed population of critically ill patients, the Glasgow Coma Scale score dominates the association between admission SOFA score and 30-day mortality. Future research into outcomes from multiple-organ dysfunction may benefit from new models for measuring organ dysfunction with special attention to neurologic dysfunction.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-04T20:45:23.415Z","creation":"2019-03-27T01:34:30Z"},"accession":"S-EPMC4140959","cross_references":{"pubmed":["25012961"],"doi":["10.1016/j.jcrc.2014.05.009"]}}