{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wells TJ"],"funding":["Medical Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["1893-904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4144740"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["211(9)"],"pubmed_abstract":["Although specific antibody induced by pathogens or vaccines is a key component of protection against infectious threats, some viruses, such as dengue, induce antibody that enhances the development of infection. In contrast, antibody-dependent enhancement of bacterial infection is largely unrecognized. Here, we demonstrate that in a significant portion of patients with bronchiectasis and Pseudomonas aeruginosa lung infection, antibody can protect the bacterium from complement-mediated killing. Strains that resist antibody-induced, complement-mediated killing produce lipopolysaccharide containing O-antigen. The inhibition of antibody-mediated killing is caused by excess production of O-antigen-specific IgG2 antibodies. Depletion of IgG2 to O-antigen restores the ability of sera to kill strai"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing."],"pmcid":["PMC4144740"],"funding_grant_id":["MC_PC_13057","G0701275","MR/L011263/1","BB/L004461/1"],"pubmed_authors":["Sevastsyanovich YR","Cunningham AF","Browning DF","Heath JN","Goodall M","O'Shea MK","Henderson IR","Whitters D","Cranston A","MacLennan CA","Wells TJ","Pravin J","De Soyza A","Stockley RA"],"additional_accession":[]},"is_claimable":false,"name":"Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing.","description":"Although specific antibody induced by pathogens or vaccines is a key component of protection against infectious threats, some viruses, such as dengue, induce antibody that enhances the development of infection. In contrast, antibody-dependent enhancement of bacterial infection is largely unrecognized. Here, we demonstrate that in a significant portion of patients with bronchiectasis and Pseudomonas aeruginosa lung infection, antibody can protect the bacterium from complement-mediated killing. Strains that resist antibody-induced, complement-mediated killing produce lipopolysaccharide containing O-antigen. The inhibition of antibody-mediated killing is caused by excess production of O-antigen-specific IgG2 antibodies. Depletion of IgG2 to O-antigen restores the ability of sera to kill strai","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2025-05-31T23:13:02.973Z","creation":"2025-05-31T23:13:02.973Z"},"accession":"S-EPMC4144740","cross_references":{"pubmed":["25113975"],"doi":["10.1084/jem.20132444"]}}