{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(15)"],"submitter":["Montes-Cano MA"],"pubmed_abstract":["<h4>Aim</h4>To assess whether CCL2 or interactions between this chemokine and its receptor (CCR2) are associated with outcomes of chronic hepatitis C and with responses to antiviral therapy.<h4>Methods</h4>Two hundred and eighty-four patients with chronic hepatitis C and 193 non-infected matched controls were included in this study. Patients were categorized according to their Scheuer score of hepatic fibrosis as F0-F2 (n = 202) or F3-F4 (n = 82) and according to their response to anti-Hepatitis C virus (HCV) therapy as sustained response (SR, n = 101) or non-sustained response (NSR, n = 98). Genotyping of the -2518 (A/G) CCL2 was performed using PCR-RFLP, genotyping of the 190 (A/G) CCR2 using a PCR-ARMS system, and genotyping of the rs3138042 (G/A) CCR2 using Taqman probes.<h4>Results</h"],"journal":["World journal of gastroenterology"],"pagination":["2187-92"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4146842"],"repository":["biostudies-literature"],"pubmed_title":["CCL2-2518 A/G and CCR2 190 A/G do not influence the outcome of hepatitis C virus infection in the Spanish population."],"pmcid":["PMC4146842"],"pubmed_authors":["Garcia-Lozano JR","Aguilar-Reina J","Romero-Gomez M","Barroso N","Montes-Cano MA","Nunez-Roldan A","Gonzalez-Escribano MF"],"additional_accession":[]},"is_claimable":false,"name":"CCL2-2518 A/G and CCR2 190 A/G do not influence the outcome of hepatitis C virus infection in the Spanish population.","description":"<h4>Aim</h4>To assess whether CCL2 or interactions between this chemokine and its receptor (CCR2) are associated with outcomes of chronic hepatitis C and with responses to antiviral therapy.<h4>Methods</h4>Two hundred and eighty-four patients with chronic hepatitis C and 193 non-infected matched controls were included in this study. Patients were categorized according to their Scheuer score of hepatic fibrosis as F0-F2 (n = 202) or F3-F4 (n = 82) and according to their response to anti-Hepatitis C virus (HCV) therapy as sustained response (SR, n = 101) or non-sustained response (NSR, n = 98). Genotyping of the -2518 (A/G) CCL2 was performed using PCR-RFLP, genotyping of the 190 (A/G) CCR2 using a PCR-ARMS system, and genotyping of the rs3138042 (G/A) CCR2 using Taqman probes.<h4>Results</h","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Apr","modification":"2025-04-25T19:32:09.01Z","creation":"2024-11-12T10:43:55.233Z"},"accession":"S-EPMC4146842","cross_references":{"pubmed":["17465499"],"doi":["10.3748/wjg.v13.i15.2187"]}}