{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qi X"],"funding":["BLRD VA"],"pagination":["4269-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4147322"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(12)"],"pubmed_abstract":["A cancer phenotype is driven by several proteins and targeting a cluster of functionally interdependent molecules should be more effective for therapeutic intervention. This is specifically important for Ras-dependent cancer, as mutated (MT) Ras is non-druggable and targeting its interaction with effectors may be essential for therapeutic intervention. Here, we report that a protein-complex activated by the Ras effector p38γ MAPK is a novel therapeutic target for K-Ras-dependent colon cancer. Unbiased proteomic screening and immune-precipitation analyses identified p38γ interaction with heat shock protein 90 (Hsp90) and K-Ras in K-Ras MT, but not wild-type (WT), colon cancer cells, indicating a role of this complex in Ras-dependent growth. Further experiments showed that this complex requi"],"journal":["Oncotarget"],"pubmed_title":["Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer."],"pmcid":["PMC4147322"],"funding_grant_id":["I01 BX002883"],"pubmed_authors":["Li G","Chesnik MA","Tsai S","Chen G","Dong L","Hou S","Lepp A","Basir Z","Szabo A","Mirza SP","Qi X","Wu S","Yin N","Xie C"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.","description":"A cancer phenotype is driven by several proteins and targeting a cluster of functionally interdependent molecules should be more effective for therapeutic intervention. This is specifically important for Ras-dependent cancer, as mutated (MT) Ras is non-druggable and targeting its interaction with effectors may be essential for therapeutic intervention. Here, we report that a protein-complex activated by the Ras effector p38γ MAPK is a novel therapeutic target for K-Ras-dependent colon cancer. Unbiased proteomic screening and immune-precipitation analyses identified p38γ interaction with heat shock protein 90 (Hsp90) and K-Ras in K-Ras MT, but not wild-type (WT), colon cancer cells, indicating a role of this complex in Ras-dependent growth. Further experiments showed that this complex requi","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-22T16:52:25.471Z","creation":"2019-03-27T01:34:48Z"},"accession":"S-EPMC4147322","cross_references":{"pubmed":["24962213"],"doi":["10.18632/oncotarget.2001"]}}