biostudies-literature00540Unknown18(9)Vieira LA<h4>Aim</h4>We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.<h4>Methods</h4>A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant.<h4>Results</h4>The results disclosed statistical difference between allele distribution among cases and controls (p=0.025, odds ratio=1.58, confidence interval=1.07-2.32) considering VDR FokI/T2C polymorphism.<h4>Conclusion</h4>The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested.Genetic testing and molecular biomarkers625-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4150369biostudies-literatureAnalysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.PMC4150369Vieira LAdos Santos AARodrigues LMDe Marchi PLFonseca FLChristofolini DMBianco BBarbosa CP54falseAnalysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.<h4>Aim</h4>We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.<h4>Methods</h4>A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant.<h4>Results</h4>The results disclosed statistical difference between allele distribution among cases and controls (p=0.025, odds ratio=1.58, confidence interval=1.07-2.32) considering VDR FokI/T2C polymorphism.<h4>Conclusion</h4>The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested.2014-01-01T00:00:00Z2014 Sep2024-11-20T00:34:06.872Z2021-02-19T19:52:59ZS-EPMC41503692500668310.1089/gtmb.2014.0030