{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu R"],"funding":["International S&T Cooperation Program"],"pagination":["924105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4151485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2014"],"pubmed_abstract":["Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polymorphisms in the genes hepatocyte nuclear factor 1 alpha (HNF1A; rs7310409, G/A), C-reactive protein (rs1800947 and rs3093059 T/C), methylenetetrahydrofolate reductase (rs1801133, C/T), and methylenetetrahydrofolate dehydrogenase (rs1076991, A/G) in 402 LMCAD and 804 more peripheral CAD patients in a Chinese population. Genotyping was performed using the matrix-assisted laser desorption/ionization tim"],"journal":["Biochemistry research international"],"pubmed_title":["A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease."],"pmcid":["PMC4151485"],"funding_grant_id":["2011BAI11B02","2010DFB33140","2011BAI11B21"],"pubmed_authors":["Liu H","Zheng Z","Hu S","Gu H","Liu R","Teng X","Zhao Y","Nie Y","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease.","description":"Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polymorphisms in the genes hepatocyte nuclear factor 1 alpha (HNF1A; rs7310409, G/A), C-reactive protein (rs1800947 and rs3093059 T/C), methylenetetrahydrofolate reductase (rs1801133, C/T), and methylenetetrahydrofolate dehydrogenase (rs1076991, A/G) in 402 LMCAD and 804 more peripheral CAD patients in a Chinese population. Genotyping was performed using the matrix-assisted laser desorption/ionization tim","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-04T12:24:35.447Z","creation":"2019-03-27T01:35:01Z"},"accession":"S-EPMC4151485","cross_references":{"pubmed":["25202455"],"doi":["10.1155/2014/924105"]}}