{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moore KM"],"funding":["Cancer Research UK","Breast Cancer Now","Medical Research Council"],"pagination":["dju169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4151855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["106(8)"],"pubmed_abstract":["Background
Integrin αvβ6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of αvβ6 has yet to be elucidated in breast cancer.Methods
Protein expression of integrin subunit beta6 (β6) was measured in breast cancers by immunohistochemistry (n > 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of β6 in breast cell lines, the role of αvβ6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, inv"],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Therapeutic targeting of integrin αvβ6 in breast cancer."],"pmcid":["PMC4151855"],"funding_grant_id":["17764","G0800825","2008MAYPR32","12008"],"pubmed_authors":["Chelala C","Marshall JF","Gabe R","Bowen R","Jones JL","Thompson AM","Hart IR","Warwick J","Moore KM","Gillett C","Thomas GJ","Jordan L","Quinlan P","Vallath S","Barry ST","Chou P","Green AR","Tapper WJ","Saha A","Ellis IO","Duffy SW","Violette S","Eccles D","Brentnall A","Brouilette K","Kendrew J","Haider S","Weinreb PH"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic targeting of integrin αvβ6 in breast cancer.","description":"Background
Integrin αvβ6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of αvβ6 has yet to be elucidated in breast cancer.Methods
Protein expression of integrin subunit beta6 (β6) was measured in breast cancers by immunohistochemistry (n > 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of β6 in breast cell lines, the role of αvβ6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, inv","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2026-04-30T08:31:17.804Z","creation":"2019-03-27T01:35:03Z"},"accession":"S-EPMC4151855","cross_references":{"pubmed":["24974129"],"doi":["10.1093/jnci/dju169"]}}