biostudies-literatureUnknown9(9)Minutolo R<h4>Background and objectives</h4>Rising prevalence of CKD requires active involvement of general practitioners to limit ESRD and mortality risk. However, the outcomes of patients with CKD exclusively managed by general practitioners are ill defined.<h4>Design, setting, participants, & measurements</h4>We prospectively evaluated 30,326 adult patients with nondialysis CKD stages 1-5 who had never received consultation in tertiary nephrology care recruited from 700 general practitioner offices in Italy during 2002 and 2003. CKD stages were classified as stages 1 and 2 (GFR ≥ 60 ml/min per 1.73 m(2) and either albuminuria or an International Classification of Diseases, Ninth Revision, Clinical Modification code for kidney disease), stage 3a (GFR=59-45), stage 3b (GFR=44-30), stage 4 (GFR=29-1Clinical journal of the American Society of Nephrology : CJASN1586-93https://www.ebi.ac.uk/biostudies/studies/S-EPMC4152817biostudies-literatureRisk of ESRD and death in patients with CKD not referred to a nephrologist: a 7-year prospective study.PMC4152817Bianchini ECricelli ICricelli CConte GMinutolo RDe Nicola LPecchioli SPiccinocchi GSimonetti MLapi FChiodini PfalseRisk of ESRD and death in patients with CKD not referred to a nephrologist: a 7-year prospective study.<h4>Background and objectives</h4>Rising prevalence of CKD requires active involvement of general practitioners to limit ESRD and mortality risk. However, the outcomes of patients with CKD exclusively managed by general practitioners are ill defined.<h4>Design, setting, participants, & measurements</h4>We prospectively evaluated 30,326 adult patients with nondialysis CKD stages 1-5 who had never received consultation in tertiary nephrology care recruited from 700 general practitioner offices in Italy during 2002 and 2003. CKD stages were classified as stages 1 and 2 (GFR ≥ 60 ml/min per 1.73 m(2) and either albuminuria or an International Classification of Diseases, Ninth Revision, Clinical Modification code for kidney disease), stage 3a (GFR=59-45), stage 3b (GFR=44-30), stage 4 (GFR=29-12014-01-01T00:00:00Z2014 Sep2025-04-04T10:08:54.182Z2019-03-27T01:35:05ZS-EPMC41528172507483810.2215/cjn.1048101310.2215/CJN.10481013