{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["National Institutes of Health National Cancer Institute","NHLBI NIH HHS","National Institutes of Health National Heart Lung and Blood Institute","NCI NIH HHS"],"pagination":["935-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4153758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(10)"],"pubmed_abstract":["Aberrant protein glycosylation is known to be associated with the development of cancers. The aberrant glycans are produced by the combined actions of changed glycosylation enzymes, substrates and transporters in glycosylation synthesis pathways in cancer cells. To identify glycosylation enzymes associated with aggressive prostate cancer (PCa), we analyzed the difference in the expression of glycosyltransferase genes between aggressive and non-aggressive PCa. Three candidate genes encoding glycosyltransferases that were elevated in aggressive PCa were subsequently selected. The expression of the three candidates was then further evaluated in androgen-dependent (LNCaP) and androgen-independent (PC3) PCa cell lines. We found that the protein expression of one of the glycosyltransferases, α ("],"journal":["Glycobiology"],"pubmed_title":["Overexpression of α (1,6) fucosyltransferase associated with aggressive prostate cancer."],"pmcid":["PMC4153758"],"funding_grant_id":["U01CA152813, 1U24CA160036","U01CA152813","T32 CA009337","1U24CA160036","N01-HV-00240","U24CA115102 and 2R01CA112314","U24CA115102","P01HL107153","2R01CA112314","U24 CA160036"],"pubmed_authors":["Choi C","Li QK","Chen J","Zhang H","Wang X","Peskoe SB","Zhang B","Platz EA"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of α (1,6) fucosyltransferase associated with aggressive prostate cancer.","description":"Aberrant protein glycosylation is known to be associated with the development of cancers. The aberrant glycans are produced by the combined actions of changed glycosylation enzymes, substrates and transporters in glycosylation synthesis pathways in cancer cells. To identify glycosylation enzymes associated with aggressive prostate cancer (PCa), we analyzed the difference in the expression of glycosyltransferase genes between aggressive and non-aggressive PCa. Three candidate genes encoding glycosyltransferases that were elevated in aggressive PCa were subsequently selected. The expression of the three candidates was then further evaluated in androgen-dependent (LNCaP) and androgen-independent (PC3) PCa cell lines. We found that the protein expression of one of the glycosyltransferases, α (","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-19T04:18:19.535Z","creation":"2019-03-27T01:35:07Z"},"accession":"S-EPMC4153758","cross_references":{"pubmed":["24906821"],"doi":["10.1093/glycob/cwu051"]}}