biostudies-literatureCerhan JRIntramural NIH HHSNCATS NIH HHSNCRR NIH HHSNIDA NIH HHSNIAID NIH HHSNIEHS NIH HHSNIDCD NIH HHSNHLBI NIH HHSNCI NIH HHSCIHR15-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC4155465biostudies-literatureUnknown2014(48)<h4>Background</h4>Although risk factors for diffuse large B-cell lymphoma (DLBCL) have been suggested, their independent effects, modification by sex, and association with anatomical sites are largely unknown.<h4>Methods</h4>In a pooled analysis of 4667 cases and 22639 controls from 19 studies, we used stepwise logistic regression to identify the most parsimonious multivariate models for DLBCL overall, by sex, and for selected anatomical sites.<h4>Results</h4>DLBCL was associated with B-cell activating autoimmune diseases (odds ratio [OR] = 2.36, 95% confidence interval [CI] = 1.80 to 3.09), hepatitis C virus seropositivity (OR = 2.02, 95% CI = 1.47 to 2.76), family history of non-Hodgkin lymphoma (OR = 1.95, 95% CI = 1.54 to 2.47), higher young adult body mass index (OR = 1.58, 95% CI = Journal of the National Cancer Institute. MonographsMedical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.PMC4155465U01 CA118444R01 CA104682R01CA104682R01 CA122663K23 CA102216R01 CA062006R01CA154643-01A1N01 PC067010CA143947R01 CA50850N01-PC-65064N01-CP-ES-11027N01-PC-67009R01CA122663R03 CA150037R01 DC014690K22 ES011027N01 CO0124005R01 CA69669-02R01 CA100555N01-PC-67008R01 CA087014N01 PC067008P50 CA130805R01 CA045614N01 PC067009N02-PC-71105N01-CO-12400R03 CA143947N01 PC065064R13 CA159842 01UL1 TR000135N01-PC-67010P50 CA097274P50 CA97274R21 CA165923R03 CA132153R01 CA154643R01 DA014690CA51086T32 HL007152R01 CA092153R01 CA051086CA92153R01 AI050850N01-CP-95618CA62006R01 CA14690UL 1 RR024160CA150037R01 CA92153-S1R01CA100555R01CA087014R01CA45614R03 CA125831CA165923R03CA132153Sampson JNSkibola CFMorton LMCerhan JRDal Maso LFlowers CRMiligi LClavel JMonnereau ABlair AKane EVRothman NPaltiel OForan JMKricker AWang SSNieters ABernstein LSlager SLfalseMedical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.<h4>Background</h4>Although risk factors for diffuse large B-cell lymphoma (DLBCL) have been suggested, their independent effects, modification by sex, and association with anatomical sites are largely unknown.<h4>Methods</h4>In a pooled analysis of 4667 cases and 22639 controls from 19 studies, we used stepwise logistic regression to identify the most parsimonious multivariate models for DLBCL overall, by sex, and for selected anatomical sites.<h4>Results</h4>DLBCL was associated with B-cell activating autoimmune diseases (odds ratio [OR] = 2.36, 95% confidence interval [CI] = 1.80 to 3.09), hepatitis C virus seropositivity (OR = 2.02, 95% CI = 1.47 to 2.76), family history of non-Hodgkin lymphoma (OR = 1.95, 95% CI = 1.54 to 2.47), higher young adult body mass index (OR = 1.58, 95% CI = 2014-01-01T00:00:00Z2014 Aug2026-05-07T07:11:37.807Z2026-04-07T22:45:08.842ZS-EPMC41554652517402310.1093/jncimonographs/lgu010