{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["48(6)"],"submitter":["Cartelle M"],"pubmed_abstract":["A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla(CTX-M-32)) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directed mutagenesis we demonstrated that this replacement is a key event in ceftazidime hydrolysis"],"journal":["Antimicrobial agents and chemotherapy"],"pagination":["2308-13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC415568"],"repository":["biostudies-literature"],"pubmed_title":["High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution."],"pmcid":["PMC415568"],"pubmed_authors":["Cartelle M","Moure R","Bou G","del Mar Tomas M","Molina F","Villanueva R"],"additional_accession":[]},"is_claimable":false,"name":"High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution.","description":"A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla(CTX-M-32)) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directed mutagenesis we demonstrated that this replacement is a key event in ceftazidime hydrolysis","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Jun","modification":"2024-11-06T02:40:45.22Z","creation":"2019-03-27T00:50:28Z"},"accession":"S-EPMC415568","cross_references":{"pubmed":["15155242"],"doi":["10.1128/AAC.48.6.2308-2313.2004","10.1128/aac.48.6.2308-2313.2004"]}}