biostudies-literatureUnknown31(9)Tahmasbpour E<h4>Background</h4>The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations.<h4>Results</h4>Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies.<h4>Conclusion</h4>Male Infertility is a complex and multifactorial disorder.<h4>Significance</h4>This review provides a comprehensive, up-to-date evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.Journal of assisted reproduction and genetics1115-37https://www.ebi.ac.uk/biostudies/studies/S-EPMC4156950biostudies-literatureA multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART).PMC4156950Agarwal ABalasubramanian DTahmasbpour EfalseA multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART).<h4>Background</h4>The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations.<h4>Results</h4>Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies.<h4>Conclusion</h4>Male Infertility is a complex and multifactorial disorder.<h4>Significance</h4>This review provides a comprehensive, up-to-date evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.2014-01-01T00:00:00Z2014 Sep2025-04-04T12:31:46.936Z2019-06-06T13:15:01ZS-EPMC41569502511764510.1007/s10815-014-0280-6