{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Biswas S"],"funding":["NCI NIH HHS"],"pagination":["517-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4157068"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(3)"],"pubmed_abstract":["Doxorubicin-loaded PEGylated liposomes (commercially available as DOXIL or Lipodox) were surface functionalized with a cell-penetrating peptide, octa-arginine (R8). For this purpose, R8-peptide was conjugated to the polyethylene glycol-dioleoyl phosphatidylethanolamine (PEG-DOPE) amphiphilic co-polymer. The resultant R8-PEG-PE conjugate was introduced into the lipid bilayer of liposomes at 2 mol% of total lipid amount via spontaneous micelle-transfer technique. The liposomal modification did not alter the particle size distribution, as measured by Particle Size Analyzer and transmission electron microscopy (TEM). However, surface-associated cationic peptide increased zeta potential of the modified liposomes. R8-functionalized liposomes (R8-Dox-L) markedly increased the intracellular and in"],"journal":["European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"],"pubmed_title":["Surface functionalization of doxorubicin-loaded liposomes with octa-arginine for enhanced anticancer activity."],"pmcid":["PMC4157068"],"funding_grant_id":["R01 CA 128486","R01 CA121838","R01 CA128486"],"pubmed_authors":["Deshpande PP","Biswas S","Dodwadkar NS","Parab S","Torchilin VP"],"additional_accession":[]},"is_claimable":false,"name":"Surface functionalization of doxorubicin-loaded liposomes with octa-arginine for enhanced anticancer activity.","description":"Doxorubicin-loaded PEGylated liposomes (commercially available as DOXIL or Lipodox) were surface functionalized with a cell-penetrating peptide, octa-arginine (R8). For this purpose, R8-peptide was conjugated to the polyethylene glycol-dioleoyl phosphatidylethanolamine (PEG-DOPE) amphiphilic co-polymer. The resultant R8-PEG-PE conjugate was introduced into the lipid bilayer of liposomes at 2 mol% of total lipid amount via spontaneous micelle-transfer technique. The liposomal modification did not alter the particle size distribution, as measured by Particle Size Analyzer and transmission electron microscopy (TEM). However, surface-associated cationic peptide increased zeta potential of the modified liposomes. R8-functionalized liposomes (R8-Dox-L) markedly increased the intracellular and in","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Aug","modification":"2025-04-19T08:54:56.37Z","creation":"2019-03-27T01:35:20Z"},"accession":"S-EPMC4157068","cross_references":{"pubmed":["23333899"],"doi":["10.1016/j.ejpb.2012.12.021"]}}