{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin L"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pagination":["41-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4157915"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["146(1)"],"pubmed_abstract":["Caloric restriction (CR) has been shown to cause tumor regression in models of triple-negative breast cancer (TNBC), and the regression is augmented when coupled with ionizing radiation (IR). In this study, we sought to determine if the molecular interaction between CR and IR could be mediated by microRNA (miR). miR arrays revealed 3 miRs in the miR-17~92 cluster as most significantly down regulated when CR is combined with IR. In vivo, CR and IR down regulated miR-17/20 in 2 TNBC models. To elucidate the mechanism by which this cluster regulates the response to CR, cDNA arrays were performed and the top 5 statistically significant gene ontology terms with high fold changes were all associated with extracellular matrix (ECM) and metastases. In silico analysis revealed 4 potential targets o"],"journal":["Breast cancer research and treatment"],"pubmed_title":["The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster."],"pmcid":["PMC4157915"],"funding_grant_id":["P30 CA056036","P30-CA56036","ZIA BC010873-03"],"pubmed_authors":["Camphausen K","Zhao S","Sano Y","Savage JE","Simone NL","Simone BA","Wickstrom E","Pestell RG","Lim M","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster.","description":"Caloric restriction (CR) has been shown to cause tumor regression in models of triple-negative breast cancer (TNBC), and the regression is augmented when coupled with ionizing radiation (IR). In this study, we sought to determine if the molecular interaction between CR and IR could be mediated by microRNA (miR). miR arrays revealed 3 miRs in the miR-17~92 cluster as most significantly down regulated when CR is combined with IR. In vivo, CR and IR down regulated miR-17/20 in 2 TNBC models. To elucidate the mechanism by which this cluster regulates the response to CR, cDNA arrays were performed and the top 5 statistically significant gene ontology terms with high fold changes were all associated with extracellular matrix (ECM) and metastases. In silico analysis revealed 4 potential targets o","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2025-06-01T01:00:46.525Z","creation":"2020-11-07T09:49:31Z"},"accession":"S-EPMC4157915","cross_references":{"pubmed":["24863696"],"doi":["10.1007/s10549-014-2978-7"]}}