biostudies-literatureHillbom MNINDS NIH HHS168-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC4160728biostudies-literatureUnknown85(2)<h4>Objective</h4>Marchiafava-Bignami disease (MBD) is a rare condition mainly associated with alcoholism, although it may be mimicked by several other disorders that cause corpus callosum lesions. Our objective was to identify helpful features for differential diagnosis and assess whether any treatment can be recommended.<h4>Methods</h4>We reviewed 122 reports containing data on 153 subjects with confirmed MBD that was associated with either alcoholism or malnutrition, and 20 reports with data on 53 subjects with conditions mimicking MBD. All the cases had been verified antemortem by brain imaging. Unconditional logistic regression was used to demonstrate factors that were associated with the outcome of MBD.<h4>Results</h4>The mimicking conditions were differentiated from MBD by the occurJournal of neurology, neurosurgery, and psychiatryDiagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.PMC4160728P50 NS072187Wszolek ZKLeone MAFujioka SSaloheimo PHillbom MJuvela SfalseDiagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.<h4>Objective</h4>Marchiafava-Bignami disease (MBD) is a rare condition mainly associated with alcoholism, although it may be mimicked by several other disorders that cause corpus callosum lesions. Our objective was to identify helpful features for differential diagnosis and assess whether any treatment can be recommended.<h4>Methods</h4>We reviewed 122 reports containing data on 153 subjects with confirmed MBD that was associated with either alcoholism or malnutrition, and 20 reports with data on 53 subjects with conditions mimicking MBD. All the cases had been verified antemortem by brain imaging. Unconditional logistic regression was used to demonstrate factors that were associated with the outcome of MBD.<h4>Results</h4>The mimicking conditions were differentiated from MBD by the occur2014-01-01T00:00:00Z2014 Feb2025-04-19T15:44:29.698Z2019-03-27T01:35:32ZS-EPMC41607282397838010.1136/jnnp-2013-305979