{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["78(12)"],"submitter":["Sugahara D"],"pubmed_abstract":["Recent studies have demonstrated an essential role of Gag-specific CD4+ T-cell responses for viral control in individuals infected with human immunodeficiency virus type 1. However, little is known about epitope specificities and functional roles of the Gag-specific helper T-cell responses in terms of vaccine-induced protection against a pathogenic retroviral challenge. We have previously demonstrated that immunization with Friend murine leukemia virus (F-MuLV) Gag proteins protects mice against the fatal Friend retrovirus (FV) infection. We report here the structure of a protective T helper cell (Th) epitope, (I)VTWEAIAVDPPP, identified in the p15 (MA) region of F-MuLV Gag. In mice immunized with the Th epitope-harboring peptide or a vaccinia virus-expressed native full-length MA protein,"],"journal":["Journal of virology"],"pagination":["6322-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC416509"],"repository":["biostudies-literature"],"pubmed_title":["Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity."],"pmcid":["PMC416509"],"pubmed_authors":["Miyazawa M","Sugahara D","Tsuji-Kawahara S"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity.","description":"Recent studies have demonstrated an essential role of Gag-specific CD4+ T-cell responses for viral control in individuals infected with human immunodeficiency virus type 1. However, little is known about epitope specificities and functional roles of the Gag-specific helper T-cell responses in terms of vaccine-induced protection against a pathogenic retroviral challenge. We have previously demonstrated that immunization with Friend murine leukemia virus (F-MuLV) Gag proteins protects mice against the fatal Friend retrovirus (FV) infection. We report here the structure of a protective T helper cell (Th) epitope, (I)VTWEAIAVDPPP, identified in the p15 (MA) region of F-MuLV Gag. In mice immunized with the Th epitope-harboring peptide or a vaccinia virus-expressed native full-length MA protein,","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Jun","modification":"2025-04-20T00:34:20.318Z","creation":"2019-03-27T00:50:28Z"},"accession":"S-EPMC416509","cross_references":{"pubmed":["15163726"],"doi":["10.1128/JVI.78.12.6322-6334.2004","10.1128/jvi.78.12.6322-6334.2004"]}}