{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Penthala NR"],"funding":["NCI/NIH","NCI Developmental Therapeutic Program (DTP)","NCI NIH HHS","Arkansas Research Alliance (ARA)"],"pagination":["1442-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4167626"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(5)"],"pubmed_abstract":["A series of novel 5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones (3a-z) have been evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3k exhibited the most potent growth inhibition against melanoma MDA-MB-435 cells (GI(50)=850 nM), against leukemia SR cancer cells (GI(50)=1.45 μM), and OVCAR-3 (GI(50)=1.26 μM) ovarian cancer cell lines. The structurally related compound 3s had a GI(50) value of 1.77 μM against MDA-MB-435 cells. The N-naphthoyl analogue 3t had GI(50) values of 1.30 and 1.91 μM against HOP-92 non-small cell lung cancer and MDA-MB-435 melanoma cell lines, respectively. The related analogue 3w had GI(50) values of 1.09 μM against HOP-92 non-small cell lung cancer cell lines. Interestingly, docking of the "],"journal":["Bioorganic & medicinal chemistry letters"],"pubmed_title":["5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties."],"pmcid":["PMC4167626"],"funding_grant_id":["R01 CA140409","CA 140409"],"pubmed_authors":["Ponugoti PR","Kasam V","Penthala NR","Crooks PA"],"additional_accession":[]},"is_claimable":false,"name":"5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties.","description":"A series of novel 5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones (3a-z) have been evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3k exhibited the most potent growth inhibition against melanoma MDA-MB-435 cells (GI(50)=850 nM), against leukemia SR cancer cells (GI(50)=1.45 μM), and OVCAR-3 (GI(50)=1.26 μM) ovarian cancer cell lines. The structurally related compound 3s had a GI(50) value of 1.77 μM against MDA-MB-435 cells. The N-naphthoyl analogue 3t had GI(50) values of 1.30 and 1.91 μM against HOP-92 non-small cell lung cancer and MDA-MB-435 melanoma cell lines, respectively. The related analogue 3w had GI(50) values of 1.09 μM against HOP-92 non-small cell lung cancer cell lines. Interestingly, docking of the ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2025-04-03T22:43:21.233Z","creation":"2019-03-27T01:35:52Z"},"accession":"S-EPMC4167626","cross_references":{"pubmed":["23339966"],"doi":["10.1016/j.bmcl.2012.12.053"]}}