{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fukushima T"],"funding":["NIAID NIH HHS","National Institutes of Health"],"pagination":["2092-100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4168784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["Iron is an essential element for all organisms, and microorganisms produce small molecule iron-chelators, siderophores, to efficiently acquire Fe(III). Gram-positive bacteria possess lipoprotein siderophore-binding proteins (SBPs) on the membrane. Some of the SBPs bind both apo-siderophores (iron-free) and Fe-siderophore (iron-chelated) and only import Fe-siderophores. When the SBP initially binds an apo-siderophore, the SBP uses the Gram-positive siderophore-shuttle mechanism (the SBPs exchange Fe(III) from a Fe-siderophore to the apo-siderophore bound to the protein) and/or displacement mechanism (the apo-siderophore bound to the SBP is released and a Fe-siderophore is then bound to the protein) to import the Fe-siderophore. Previously, we reported that the Bacillus cereus SBP, YxeB, exc"],"journal":["ACS chemical biology"],"pubmed_title":["Direct evidence of iron uptake by the Gram-positive siderophore-shuttle mechanism without iron reduction."],"pmcid":["PMC4168784"],"funding_grant_id":["R01 AI011744","AI11744"],"pubmed_authors":["Allred BE","Raymond KN","Fukushima T"],"additional_accession":[]},"is_claimable":false,"name":"Direct evidence of iron uptake by the Gram-positive siderophore-shuttle mechanism without iron reduction.","description":"Iron is an essential element for all organisms, and microorganisms produce small molecule iron-chelators, siderophores, to efficiently acquire Fe(III). Gram-positive bacteria possess lipoprotein siderophore-binding proteins (SBPs) on the membrane. Some of the SBPs bind both apo-siderophores (iron-free) and Fe-siderophore (iron-chelated) and only import Fe-siderophores. When the SBP initially binds an apo-siderophore, the SBP uses the Gram-positive siderophore-shuttle mechanism (the SBPs exchange Fe(III) from a Fe-siderophore to the apo-siderophore bound to the protein) and/or displacement mechanism (the apo-siderophore bound to the SBP is released and a Fe-siderophore is then bound to the protein) to import the Fe-siderophore. Previously, we reported that the Bacillus cereus SBP, YxeB, exc","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-22T21:08:52.041Z","creation":"2019-03-27T01:35:56Z"},"accession":"S-EPMC4168784","cross_references":{"pubmed":["25007174"],"doi":["10.1021/cb500319n"]}}