{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(15)"],"submitter":["Berdiel-Acer M"],"pubmed_abstract":["Based on 108 differentially expressed genes between carcinoma-associated fibroblasts (CAFs) and paired normal colonic fibroblasts we recently reported, a 5-gene classifier for relapse prediction in Stage II/III colorectal cancer (CRC ) was developed. Its predictive value was validated in datasets GSE17538, GSE33113 and GSE14095. An additional validation was performed in a metacohort (n=317) and 142 CRC patients by means of RT-PCR. The 5-gene classifier was significantly associated with increased relapse risk and death from CRC across all validation series of Stage II/III patients used. Multivariate Cox regression analyses confirmed the independent prognostic value of the stromal classifier (HR=2.67; P=0.002). Post-test probabilities provided evidence of the suitability of the 5-gene classi"],"journal":["Oncotarget"],"pagination":["6437-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4171642"],"repository":["biostudies-literature"],"pubmed_title":["A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer."],"pmcid":["PMC4171642"],"pubmed_authors":["Santos C","Sanz-Pamplona R","Berenguer A","Cuadras D","Salazar R","Moreno V","Mollevi DG","Capella G","Paules MJ","Berdiel-Acer M","Villanueva A","Sanjuan X"],"additional_accession":[]},"is_claimable":false,"name":"A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer.","description":"Based on 108 differentially expressed genes between carcinoma-associated fibroblasts (CAFs) and paired normal colonic fibroblasts we recently reported, a 5-gene classifier for relapse prediction in Stage II/III colorectal cancer (CRC ) was developed. Its predictive value was validated in datasets GSE17538, GSE33113 and GSE14095. An additional validation was performed in a metacohort (n=317) and 142 CRC patients by means of RT-PCR. The 5-gene classifier was significantly associated with increased relapse risk and death from CRC across all validation series of Stage II/III patients used. Multivariate Cox regression analyses confirmed the independent prognostic value of the stromal classifier (HR=2.67; P=0.002). Post-test probabilities provided evidence of the suitability of the 5-gene classi","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2026-05-02T09:00:36.113Z","creation":"2019-03-27T01:36:11Z"},"accession":"S-EPMC4171642","cross_references":{"pubmed":["25115384"],"doi":["10.18632/oncotarget.2237"]}}