{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Penthala NR"],"funding":["Arkansas Research Alliance","National Cancer Institute","NCI NIH HHS","NIH"],"pagination":["5562-5565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4175744"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(40)"],"pubmed_abstract":["Use of a novel reagent has been established for the synthesis of a series of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles (<b>6a-i</b> and <b>9a-e</b>) from cyanostilbene analogs of benzo[<i>b</i>]thiophene, benzo[<i>b</i>]furan and indole, catalyzed by L-proline via Lewis base-catalyzed one-step [3+2]cycloaddition of azide. This method provides an efficient, simple and environmentally benign procedure that affords good yields and relatively short reaction times."],"journal":["Tetrahedron letters"],"pubmed_title":["L-Proline catalyzed one-step synthesis of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide."],"pmcid":["PMC4175744"],"funding_grant_id":["R01 CA140409","CA140409"],"pubmed_authors":["Madadi NR","Janganati V","Penthala NR","Crooks PA"],"additional_accession":[]},"is_claimable":false,"name":"L-Proline catalyzed one-step synthesis of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide.","description":"Use of a novel reagent has been established for the synthesis of a series of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles (<b>6a-i</b> and <b>9a-e</b>) from cyanostilbene analogs of benzo[<i>b</i>]thiophene, benzo[<i>b</i>]furan and indole, catalyzed by L-proline via Lewis base-catalyzed one-step [3+2]cycloaddition of azide. This method provides an efficient, simple and environmentally benign procedure that affords good yields and relatively short reaction times.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-22T21:57:35.41Z","creation":"2019-03-27T01:36:29Z"},"accession":"S-EPMC4175744","cross_references":{"pubmed":["25267862"],"doi":["10.1016/j.tetlet.2014.08.027"]}}