biostudies-literaturePenthala NRArkansas Research AllianceNational Cancer InstituteNCI NIH HHSNIH5562-5565https://www.ebi.ac.uk/biostudies/studies/S-EPMC4175744biostudies-literatureUnknown55(40)Use of a novel reagent has been established for the synthesis of a series of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles (<b>6a-i</b> and <b>9a-e</b>) from cyanostilbene analogs of benzo[<i>b</i>]thiophene, benzo[<i>b</i>]furan and indole, catalyzed by L-proline via Lewis base-catalyzed one-step [3+2]cycloaddition of azide. This method provides an efficient, simple and environmentally benign procedure that affords good yields and relatively short reaction times.Tetrahedron lettersL-Proline catalyzed one-step synthesis of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide.PMC4175744R01 CA140409CA140409Madadi NRJanganati VPenthala NRCrooks PAfalseL-Proline catalyzed one-step synthesis of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide.Use of a novel reagent has been established for the synthesis of a series of 4,5-diaryl-2<i>H</i>-1,2,3-triazoles (<b>6a-i</b> and <b>9a-e</b>) from cyanostilbene analogs of benzo[<i>b</i>]thiophene, benzo[<i>b</i>]furan and indole, catalyzed by L-proline via Lewis base-catalyzed one-step [3+2]cycloaddition of azide. This method provides an efficient, simple and environmentally benign procedure that affords good yields and relatively short reaction times.2014-01-01T00:00:00Z2014 Oct2025-04-22T21:57:35.41Z2019-03-27T01:36:29ZS-EPMC41757442526786210.1016/j.tetlet.2014.08.027