{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Montoya D"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["250ra114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4175914"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(250)"],"pubmed_abstract":["Tuberculosis is a leading cause of infectious disease-related death worldwide; however, only 10% of people infected with Mycobacterium tuberculosis develop disease. Factors that contribute to protection could prove to be promising targets for M. tuberculosis therapies. Analysis of peripheral blood gene expression profiles of active tuberculosis patients has identified correlates of risk for disease or pathogenesis. We sought to identify potential human candidate markers of host defense by studying gene expression profiles of macrophages, cells that, upon infection by M. tuberculosis, can mount an antimicrobial response. Weighted gene coexpression network analysis revealed an association between the cytokine interleukin-32 (IL-32) and the vitamin D antimicrobial pathway in a network of inte"],"journal":["Science translational medicine"],"pubmed_title":["IL-32 is a molecular marker of a host defense network in human tuberculosis."],"pmcid":["PMC4175914"],"funding_grant_id":["R01 AI022553","T32 GM008042","T32 GM007185","P50 AR063020","R01 HL119068","R01 AI047868","R01AI022553","R25 GM055052"],"pubmed_authors":["Hewison M","Liu PT","Pellegrini M","Modlin RL","Bloom BR","Horvath S","Inkeles MS","Schenk M","Adams JS","Teles RM","Chun R","Vaidya P","Swindell WR","Zavala K","Realegeno S","Montoya D","Munoz MA"],"additional_accession":[]},"is_claimable":false,"name":"IL-32 is a molecular marker of a host defense network in human tuberculosis.","description":"Tuberculosis is a leading cause of infectious disease-related death worldwide; however, only 10% of people infected with Mycobacterium tuberculosis develop disease. Factors that contribute to protection could prove to be promising targets for M. tuberculosis therapies. Analysis of peripheral blood gene expression profiles of active tuberculosis patients has identified correlates of risk for disease or pathogenesis. We sought to identify potential human candidate markers of host defense by studying gene expression profiles of macrophages, cells that, upon infection by M. tuberculosis, can mount an antimicrobial response. Weighted gene coexpression network analysis revealed an association between the cytokine interleukin-32 (IL-32) and the vitamin D antimicrobial pathway in a network of inte","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2026-05-04T23:32:12.003Z","creation":"2019-03-27T01:36:30Z"},"accession":"S-EPMC4175914","cross_references":{"pubmed":["25143364"],"doi":["10.1126/scitranslmed.3009546"]}}