{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Joie C"],"funding":["European Research Council"],"pagination":["799-808"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4178285"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(6)"],"pubmed_abstract":["The organocatalytic asymmetric synthesis of functionalized 1,3,5-triarylpyrrolidin-2-ones bearing three contiguous stereocenters through an aza-Michael/aldol domino reaction of α-ketoamides with α,β-unsaturated aldehydes is described. The domino products were further derivatized by aldehyde olefination under one-pot conditions. The reaction proceeds with excellent diastereoselectivities (>20:1) and good to excellent enantioselectivities (60-96% ee)."],"journal":["Synthesis"],"pubmed_title":["Organocatalytic Asymmetric Synthesis of Functionalized 1,3,5-Triarylpyrrolidin-2-ones via an Aza-Michael/Aldol Domino Reaction."],"pmcid":["PMC4178285"],"funding_grant_id":["320493"],"pubmed_authors":["Joie C","Deckers K","Enders D"],"additional_accession":[]},"is_claimable":false,"name":"Organocatalytic Asymmetric Synthesis of Functionalized 1,3,5-Triarylpyrrolidin-2-ones via an Aza-Michael/Aldol Domino Reaction.","description":"The organocatalytic asymmetric synthesis of functionalized 1,3,5-triarylpyrrolidin-2-ones bearing three contiguous stereocenters through an aza-Michael/aldol domino reaction of α-ketoamides with α,β-unsaturated aldehydes is described. The domino products were further derivatized by aldehyde olefination under one-pot conditions. The reaction proceeds with excellent diastereoselectivities (>20:1) and good to excellent enantioselectivities (60-96% ee).","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Mar","modification":"2025-04-22T20:40:20.153Z","creation":"2019-03-27T01:36:38Z"},"accession":"S-EPMC4178285","cross_references":{"pubmed":["25278634"],"doi":["10.1055/s-0033-1340565"]}}