{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Narayanapillai SC"],"funding":["NCI NIH HHS"],"pagination":["2365-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4178470"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(10)"],"pubmed_abstract":["We have previously shown that kava and its flavokavain-free Fraction B completely blocked 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice with a preferential reduction in NNK-induced O (6)-methylguanine (O (6)-mG). In this study, we first identified natural (+)-dihydromethysticin (DHM) as a lead compound through evaluating the in vivo efficacy of five major compounds in Fraction B on reducing O (6)-mG in lung tissues. (+)-DHM demonstrated outstanding chemopreventive activity against NNK-induced lung tumorigenesis in A/J mice with 97% reduction of adenoma multiplicity at a dose of 0.05mg/g of diet (50 ppm). Synthetic (±)-DHM was equally effective as the natural (+)-DHM in these bioassays while a structurally similar analog, (+)-dihydrokavain (DHK)"],"journal":["Carcinogenesis"],"pubmed_title":["Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice."],"pmcid":["PMC4178470"],"funding_grant_id":["R01 CA193278","P01 CA138338","P30 CA077598","R01 CA142649","R01 CA81301"],"pubmed_authors":["O'Sullivan MG","Peterson LA","Hecht SS","Zhou B","Lu J","Xing C","Narayanapillai SC","Shaik AA","Balbo S","Leitzman P","Grill AE","Upadhyaya P"],"additional_accession":[]},"is_claimable":false,"name":"Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.","description":"We have previously shown that kava and its flavokavain-free Fraction B completely blocked 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice with a preferential reduction in NNK-induced O (6)-methylguanine (O (6)-mG). In this study, we first identified natural (+)-dihydromethysticin (DHM) as a lead compound through evaluating the in vivo efficacy of five major compounds in Fraction B on reducing O (6)-mG in lung tissues. (+)-DHM demonstrated outstanding chemopreventive activity against NNK-induced lung tumorigenesis in A/J mice with 97% reduction of adenoma multiplicity at a dose of 0.05mg/g of diet (50 ppm). Synthetic (±)-DHM was equally effective as the natural (+)-DHM in these bioassays while a structurally similar analog, (+)-dihydrokavain (DHK)","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-22T20:38:49.621Z","creation":"2019-03-27T01:36:40Z"},"accession":"S-EPMC4178470","cross_references":{"pubmed":["25053626"],"doi":["10.1093/carcin/bgu149"]}}