{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weiskopf D"],"funding":["NIAID NIH HHS"],"pagination":["11383-94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4178794"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(19)"],"pubmed_abstract":["<h4>Unlabelled</h4>Dengue virus (DENV) is the causative agent of dengue fever (DF). This disease can be caused by any of four DENV serotypes (DENV1 to -4) which share 67 to 75% sequence homology with one another. The effect of subsequent infections with different serotypes on the T cell repertoire is not fully understood. We utilized mice transgenic for human leukocyte antigens (HLA) lacking the alpha/beta interferon (IFN-α/β) receptor to study responses to heterologous DENV infection. First, we defined the primary T cell response to DENV3 in the context of a wide range of HLA molecules. The primary DENV3 immune response recognized epitopes derived from all 10 DENV proteins, with a significant fraction of the response specific for structural proteins. This is in contrast to primary DENV2 i"],"journal":["Journal of virology"],"pubmed_title":["Immunodominance changes as a function of the infecting dengue virus serotype and primary versus secondary infection."],"pmcid":["PMC4178794"],"funding_grant_id":["HHSN272200900042C","U54AI057517"],"pubmed_authors":["Weiskopf D","Peters B","Sette A","Angelo MA","Sidney J","Shresta S"],"additional_accession":[]},"is_claimable":false,"name":"Immunodominance changes as a function of the infecting dengue virus serotype and primary versus secondary infection.","description":"<h4>Unlabelled</h4>Dengue virus (DENV) is the causative agent of dengue fever (DF). This disease can be caused by any of four DENV serotypes (DENV1 to -4) which share 67 to 75% sequence homology with one another. The effect of subsequent infections with different serotypes on the T cell repertoire is not fully understood. We utilized mice transgenic for human leukocyte antigens (HLA) lacking the alpha/beta interferon (IFN-α/β) receptor to study responses to heterologous DENV infection. First, we defined the primary T cell response to DENV3 in the context of a wide range of HLA molecules. The primary DENV3 immune response recognized epitopes derived from all 10 DENV proteins, with a significant fraction of the response specific for structural proteins. This is in contrast to primary DENV2 i","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-22T20:42:01.229Z","creation":"2019-03-27T01:36:41Z"},"accession":"S-EPMC4178794","cross_references":{"pubmed":["25056881"],"doi":["10.1128/jvi.01108-14","10.1128/JVI.01108-14"]}}