biostudies-literatureWeiskopf DNIAID NIH HHS11383-94https://www.ebi.ac.uk/biostudies/studies/S-EPMC4178794biostudies-literatureUnknown88(19)<h4>Unlabelled</h4>Dengue virus (DENV) is the causative agent of dengue fever (DF). This disease can be caused by any of four DENV serotypes (DENV1 to -4) which share 67 to 75% sequence homology with one another. The effect of subsequent infections with different serotypes on the T cell repertoire is not fully understood. We utilized mice transgenic for human leukocyte antigens (HLA) lacking the alpha/beta interferon (IFN-α/β) receptor to study responses to heterologous DENV infection. First, we defined the primary T cell response to DENV3 in the context of a wide range of HLA molecules. The primary DENV3 immune response recognized epitopes derived from all 10 DENV proteins, with a significant fraction of the response specific for structural proteins. This is in contrast to primary DENV2 iJournal of virologyImmunodominance changes as a function of the infecting dengue virus serotype and primary versus secondary infection.PMC4178794HHSN272200900042CU54AI057517Weiskopf DPeters BSette AAngelo MASidney JShresta SfalseImmunodominance changes as a function of the infecting dengue virus serotype and primary versus secondary infection.<h4>Unlabelled</h4>Dengue virus (DENV) is the causative agent of dengue fever (DF). This disease can be caused by any of four DENV serotypes (DENV1 to -4) which share 67 to 75% sequence homology with one another. The effect of subsequent infections with different serotypes on the T cell repertoire is not fully understood. We utilized mice transgenic for human leukocyte antigens (HLA) lacking the alpha/beta interferon (IFN-α/β) receptor to study responses to heterologous DENV infection. First, we defined the primary T cell response to DENV3 in the context of a wide range of HLA molecules. The primary DENV3 immune response recognized epitopes derived from all 10 DENV proteins, with a significant fraction of the response specific for structural proteins. This is in contrast to primary DENV2 i2014-01-01T00:00:00Z2014 Oct2025-04-22T20:42:01.229Z2019-03-27T01:36:41ZS-EPMC41787942505688110.1128/jvi.01108-1410.1128/JVI.01108-14