{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hirbod T"],"funding":["NIAID NIH HHS","CIHR"],"pagination":["e1004416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4183701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["<h4>Background</h4>The foreskin is the site of most HIV acquisition in uncircumcised heterosexual men. Although HIV-exposed, seronegative (HESN) uncircumcised men demonstrate HIV-neutralizing IgA and increased antimicrobial peptides (AMPs) in the foreskin prepuce, no prospective studies have examined the mucosal immune correlates of HIV acquisition.<h4>Methods</h4>To assess the association of foreskin immune parameters with HIV acquisition, antimicrobial peptides and IgA with the capacity to neutralize a primary clade C HIV strain were quantified by blinded investigators, using sub-preputial swabs collected longitudinally during a randomized trial of male circumcision for HIV prevention in Rakai, Uganda.<h4>Results</h4>Participants were 99 men who acquired HIV (cases) and 109 randomly sele"],"journal":["PLoS pathogens"],"pubmed_title":["HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men."],"pmcid":["PMC4183701"],"funding_grant_id":["R01AI087409-01A1","U01 AI051171","U01AI51171","R01 AI087409","HBF-126787"],"pubmed_authors":["Prodger JL","Gommerman JL","Kigozi G","Gray RH","Serwadda D","Nalugoda F","Shahabi K","Wawer MJ","Broliden K","Kaul R","Hirbod T","Kong X","Tobian AA","Ndyanabo A","Rojas OL"],"additional_accession":[]},"is_claimable":false,"name":"HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.","description":"<h4>Background</h4>The foreskin is the site of most HIV acquisition in uncircumcised heterosexual men. Although HIV-exposed, seronegative (HESN) uncircumcised men demonstrate HIV-neutralizing IgA and increased antimicrobial peptides (AMPs) in the foreskin prepuce, no prospective studies have examined the mucosal immune correlates of HIV acquisition.<h4>Methods</h4>To assess the association of foreskin immune parameters with HIV acquisition, antimicrobial peptides and IgA with the capacity to neutralize a primary clade C HIV strain were quantified by blinded investigators, using sub-preputial swabs collected longitudinally during a randomized trial of male circumcision for HIV prevention in Rakai, Uganda.<h4>Results</h4>Participants were 99 men who acquired HIV (cases) and 109 randomly sele","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-05-29T20:07:47.615Z","creation":"2019-03-27T01:36:55Z"},"accession":"S-EPMC4183701","cross_references":{"pubmed":["25275513"],"doi":["10.1371/journal.ppat.1004416"]}}