biostudies-literatureUnknown54(4)Pathak RSuperoxide dismutase (SOD), a well known antioxidant enzyme, is known to exert its presence across bacteria to humans. Apart from their well-known antioxidant defense mechanisms, their association with various extremophiles in response to various stress conditions is poorly understood. Here, we have discussed the conservation and the prevalence of SODs among 21 representative extremophiles. A systematic investigation of aligned amino acid sequences of SOD from all the selected extremophiles revealed a consensus motif D-[VLE]-[FW]-E-H-[AS]-Y-[YM]. To computationally predict the correlation of SOD with the various stress conditions encountered by these extremophiles, Exiguobacterium was selected as a model organism which is known to survive under various adverse extremophilic conditions. IntIndian journal of microbiology450-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4186928biostudies-literatureHomology modeling and comparative profiling of superoxide dismutase among extremophiles: exiguobacterium as a model organism.PMC4186928Narang PPathak RChandra MSharma PKKumar RGautam HKfalseHomology modeling and comparative profiling of superoxide dismutase among extremophiles: exiguobacterium as a model organism.Superoxide dismutase (SOD), a well known antioxidant enzyme, is known to exert its presence across bacteria to humans. Apart from their well-known antioxidant defense mechanisms, their association with various extremophiles in response to various stress conditions is poorly understood. Here, we have discussed the conservation and the prevalence of SODs among 21 representative extremophiles. A systematic investigation of aligned amino acid sequences of SOD from all the selected extremophiles revealed a consensus motif D-[VLE]-[FW]-E-H-[AS]-Y-[YM]. To computationally predict the correlation of SOD with the various stress conditions encountered by these extremophiles, Exiguobacterium was selected as a model organism which is known to survive under various adverse extremophilic conditions. Int2014-01-01T00:00:00Z2014 Dec2026-05-07T04:52:05.645Z2025-05-29T19:21:55.403ZS-EPMC41869282532044510.1007/s12088-014-0482-8