{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["82(10)"],"submitter":["Eleftherianos I"],"pubmed_abstract":["Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and investigated their response against two pathogenic bacteria (Photorhabdus luminescens and Enterococcus faecalis) and two nonpathogenic bacteria (Escherichia coli and Micrococcus luteus). We detected high sensitivity among YW flies to bacterial infections and increased bacterial growth compared to the other strains. We also found variation in the transcription of certain antimicrobial peptide genes among strains, with Oregon and YW infected flies showing the highest and lowest g"],"journal":["Infection and immunity"],"pagination":["4169-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4187883"],"repository":["biostudies-literature"],"pubmed_title":["Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections."],"pmcid":["PMC4187883"],"pubmed_authors":["Khojandi A","Spivack S","Shukla S","More K","Paulin E","Eleftherianos I"],"additional_accession":[]},"is_claimable":false,"name":"Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections.","description":"Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and investigated their response against two pathogenic bacteria (Photorhabdus luminescens and Enterococcus faecalis) and two nonpathogenic bacteria (Escherichia coli and Micrococcus luteus). We detected high sensitivity among YW flies to bacterial infections and increased bacterial growth compared to the other strains. We also found variation in the transcription of certain antimicrobial peptide genes among strains, with Oregon and YW infected flies showing the highest and lowest g","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2026-05-03T21:28:12.981Z","creation":"2019-03-27T01:37:09Z"},"accession":"S-EPMC4187883","cross_references":{"pubmed":["25047850"],"doi":["10.1128/IAI.02318-14","10.1128/iai.02318-14"]}}