{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bauer M"],"funding":["Austrian Science Fund FWF"],"pagination":["1326-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4189097"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["83(15)"],"pubmed_abstract":["<h4>Objectives</h4>To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure frequency and antiepileptic drug load are associated with changes in Pgp function.<h4>Methods</h4>Seven patients with drug-resistant temporal lobe epilepsy underwent VPM-PET scans pre- and postsurgery. Patients were followed up for a median of 6 years (range 4-7) after surgery. Pgp immunoreactivity in surgically resected hippocampal specimens was determined with immunohistochemistry.<h4>Results</h4>Optimal surgical outcome, defined as seizure freedom and withdrawal of antiepileptic drugs, was"],"journal":["Neurology"],"pubmed_title":["In vivo P-glycoprotein function before and after epilepsy surgery."],"pmcid":["PMC4189097"],"funding_grant_id":["F 3513","KLI 139","F 3513-B20"],"pubmed_authors":["Liu J","Muller M","Zeitlinger M","Asselin MC","Sisodiya SM","Langer O","Bauer M","Mitterhauser M","Wadsak W","Hainfellner JA","Pataraia E","Karch R","Koepp MJ"],"additional_accession":[]},"is_claimable":false,"name":"In vivo P-glycoprotein function before and after epilepsy surgery.","description":"<h4>Objectives</h4>To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure frequency and antiepileptic drug load are associated with changes in Pgp function.<h4>Methods</h4>Seven patients with drug-resistant temporal lobe epilepsy underwent VPM-PET scans pre- and postsurgery. Patients were followed up for a median of 6 years (range 4-7) after surgery. Pgp immunoreactivity in surgically resected hippocampal specimens was determined with immunohistochemistry.<h4>Results</h4>Optimal surgical outcome, defined as seizure freedom and withdrawal of antiepileptic drugs, was","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-05T00:20:49.311Z","creation":"2019-03-27T01:37:11Z"},"accession":"S-EPMC4189097","cross_references":{"pubmed":["25186858"],"doi":["10.1212/WNL.0000000000000858"]}}